Diabetes if not controlled can affect the eyes, the feet, the kidneys, can cause strokes as well as other problems. The best treatment for all of the associated conditions is to tightly control the diabetes but if the eyes are finally affected with diabetic retinopathy what can be done?
Significant diabetic retinopathy dramatically slows down the
blood flow to the retina. The body has an instinctive defense
mechanism when it perceives that there is not enough blood flow to a
given area - it creates new blood vessels to try and redirect blood,
nutrients and oxygen to the starved areas.
These new blood vessels are stimulated into growing by the release of a natural chemical called vascular endothelial growth factor (VEGF).
Unfortunately these blood vessels even though they are formed for the
good of the retina, tend to be very fragile and can leak or
haemorrhage. This in turn creates a vicious cycle, which causes more
damage to the retina. Left untreated it can ultimately lead to blindness.
Treatments
Historically diabetic retinopathy has been treated with laser. It is called laser photocoagulation.
The irony of laser is that it actually burns and destroys retinal tissue so that there is less demand on the blood flow to the remaining surviving retina. Typically this restricts peripheral vision so that the central vision is spared. Central vision is required to read, watch TV and recognise faces.
Laser surgery can also be performed in the central part of the retina called the macula if there is leakage there. It is done in a much more gentle fashion called focal grid laser, so again the central vision can be spared.
The most famous study that was conducted to show the benefit of laser treatment for diabetic retinopathy was performed in the 1990's. It was called Early Treatment Diabetic Retinopathy Study and was sponsored by the National Eye Institute - NEI showed (USA government funded to promote Eye Research). This massive study went on to show that laser photocoagulation had a big role to play in trying to preserve the sight of people that were suffering from diabetic retinopathy.

So what is new?
As mentioned before damage to retina occurs because of fragile new blood vessels that form due to the presence of the chemical VEGF. Wouldn't it make sense then if this chemical could be blocked, new vessels would be less likely to form and hence the retina less likely to be damaged. This in turn would preserve vision.
A recent study again sponsored by the NEI showed that by injected an anti-VEGF drug into the eye called Lucentis on a regular basis did in fact protect eyes from the damage of diabetic retinopathy. What was interesting was that the results were superior to laser.
The issue with anti-VEGF therapy at the moment is that ongoing injections are required to maintain vision. Apart from being very inconvenient and costly, there is a small risk each time that a major complication could occur.
Ultimately this type of therapy is likely to be evolved into some sort of slow release implant that will be effective over a long period of time - say five years.
Treating eyes with anti-VEGF injections has become the mainstay treatment for macular degeneration now for a few years. Surgical centres have become overwhelmed with treating these patients as many of them require injections every month.
If we add diabetic retinopathy to the system as well every month or two, treating eye disease will become an extremely labour intensive procedure. Either more eye surgeons will need to be trained, or maybe optometrists will be trained at either the diagnostic or treatment level if slow release implants do not come to fruition.
It might be scary to imagine having an injection in your eye every month, but what is even scarier is the thought of going blind!
Most patients will tell you that even though the injection process is not pleasant it is far from tortuous. They are delighted that something can be done to protect their most precious sense - THEIR VISION!
At The Eye Practice we test the eyes of diabetics all the time. We are equipped at the highest possible level to detect the beginnings of diabetic retinopathy. We also have great working relationships with the best diabetic retinal surgeons, who we would refer you to immediately if treatment was indicated.
Call us on 92901 1899 or BOOK AN APPOINTMENT HERE for your diabetic retina check. This should be done yearly if you are diabetic.